Ioannis Iliopoulos

Year	Rank	Type	Title / Venue / Authors
2023	J	`jnl`	CGG toolkit: Software components for computational genomics. PLoS Comput. Biol. Dimitrios Vasileiou, Christos Karapiperis, Ismini Baltsavia, Anastasia Chasapi, Dag G. Ahrén, Paul J. Janssen, Ioannis Iliopoulos, Vasilis J. Promponas, Anton J. Enright, Christos A. Ouzounis
2023	C	`conf`	STEAM Project Exhibition in the Metaverse for Deaf High School Students' Affective Empowerment: The Power of Student Museum Exhibitions in Social Virtual Reality. iLRN Stylianos Mystakidis, Peny Theologi-Gouti, Ioannis Iliopoulos
2021	J	`jnl`	Enhancement of Penetration of Millimeter Waves by Field Focusing Applied to Breast Cancer Detection. IEEE Trans. Biomed. Eng. Ioannis Iliopoulos, Simona Di Meo, Marco Pasian, Maxim Zhadobov, Philippe Pouliguen, Patrick Potier, Luca Perregrini, Ronan Sauleau, Mauro Ettorre
2021	J	`jnl`	ProteoSign v2: a faster and evolved user-friendly online tool for statistical analyses of differential proteomics. Nucleic Acids Res. Evangelos Theodorakis, Andreas N. Antonakis, Ismini Baltsavia, Georgios A. Pavlopoulos, Martina Samiotaki, Grigoris D. Amoutzias, Theodosios Theodosiou, Oreste Acuto, Georgios Efstathiou, Ioannis Iliopoulos
2019	J	`jnl`	Establishment of computational biology in Greece and Cyprus: Past, present, and future. PLoS Comput. Biol. Anastasia Chasapi, Michalis Aivaliotis, Lefteris Angelis, Anastasios Chanalaris, Ioannis Iliopoulos, Ilias Kappas, Christos Karapiperis, Nikos Kyrpides, Evangelos Pafilis, Eleftherios Panteris, Pantelis Topalis, George Tsiamis, Ioannis S. Vizirianakis, Metaxia Vlassi, Vasilis J. Promponas, Christos A. Ouzounis
2017	J	`jnl`	Empirical Comparison of Visualization Tools for Larger-Scale Network Analysis. Adv. Bioinformatics Georgios A. Pavlopoulos, David Páez-Espino, Nikos Kyrpides, Ioannis Iliopoulos
2017	J	`jnl`	ProteoSign: an end-user online differential proteomics statistical analysis platform. Nucleic Acids Res. Georgios Efstathiou, Andreas N. Antonakis, Georgios A. Pavlopoulos, Theodosios Theodosiou, Peter Divanach, David C. Trudgian, Benjamin Thomas, Nikolas Papanikolaou, Michalis Aivaliotis, Oreste Acuto, Ioannis Iliopoulos
2016	J	`jnl`	DrugQuest - a text mining workflow for drug association discovery. BMC Bioinform. Nikolas Papanikolaou, Georgios A. Pavlopoulos, Theodosios Theodosiou, Ioannis S. Vizirianakis, Ioannis Iliopoulos
2015	J	`jnl`	BioTextQuest+: a knowledge integration platform for literature mining and concept discovery. Bioinform. Nikolas Papanikolaou, Georgios A. Pavlopoulos, Evangelos Pafilis, Theodosios Theodosiou, Reinhard Schneider, Venkata P. Satagopam, Christos A. Ouzounis, Aristides G. Eliopoulos, Vasilis J. Promponas, Ioannis Iliopoulos
2014	J	`jnl`	BioTextQuest Bioinform. Nikolas Papanikolaou, Georgios A. Pavlopoulos, Evangelos Pafilis, Theodosios Theodosiou, Reinhard Schneider, Venkata P. Satagopam, Christos A. Ouzounis, Aristides G. Eliopoulos, Vasilis J. Promponas, Ioannis Iliopoulos
2014	J	`jnl`	Experimental evidence validating the computational inference of functional associations from gene fusion events: a critical survey. Briefings Bioinform. Vasilis J. Promponas, Christos A. Ouzounis, Ioannis Iliopoulos
2013	C	`conf`	OnTheFly 2.0: A tool for automatic annotation of files and biological information extraction. BIBE Evangelos Pafilis, Georgios A. Pavlopoulos, Venkata P. Satagopam, Nikolas Papanikolaou, Heiko Horn, Christos Arvanitidis, Lars Juhl Jensen, Reinhard Schneider, Ioannis Iliopoulos
2013	J	`jnl`	Unraveling genomic variation from next generation sequencing data. BioData Min. Georgios A. Pavlopoulos, Anastasis Oulas, Ernesto Iacucci, Alejandro Sifrim, Yves Moreau, Reinhard Schneider, Jan Aerts, Ioannis Iliopoulos
2011	J	`jnl`	BioTextQuest: a web-based biomedical text mining suite for concept discovery. Bioinform. Nikolas Papanikolaou, Evangelos Pafilis, Stavros Nikolaou, Christos A. Ouzounis, Ioannis Iliopoulos, Vasilis J. Promponas
2009	J	`jnl`	NOBLAST and JAMBLAST: New Options for BLAST and a Java Application Manager for BLAST results. Bioinform. Jacques Lagnel, Costas S. Tsigenopoulos, Ioannis Iliopoulos
2003	J	`jnl`	Evaluation of annotation strategies using an entire genome sequence. Bioinform. Ioannis Iliopoulos, Sophia Tsoka, Miguel A. Andrade, Anton J. Enright, Mark Carroll, Patrick Poullet, Vasilis J. Promponas, Theodore Liakopoulos, Giorgos Palaios, Claude Pasquier, Stavros J. Hamodrakas, Javier Tamames, Asutosh T. Yagnik, Anna Tramontano, Damien Devos, Christian Blaschke, Alfonso Valencia, David Brett, David M. A. Martin, Christophe Leroy, Isidore Rigoutsos, Chris Sander, Christos A. Ouzounis
2001	Misc	`conf`	TEXTQUEST: Document Clustering of MEDLINE Abstracts For Concept Discovery In Molecular Biology. Pacific Symposium on Biocomputing Ioannis Iliopoulos, Anton J. Enright, Christos A. Ouzounis

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Definitions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "import clickhouse_connect"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "\n",
    "ch_TEST_client = clickhouse_connect.get_client(host='e.rationaledge.io', port=443, username='default', password='werioubTGwvf0-dsbv_', database='redb', verify=False)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [],
   "source": [
    "ch_TEST_BETA_client = clickhouse_connect.get_client(host='k.rationaledge.io', port=443, username='default', password='werioubTGwvf0-dsbv_', database='default', verify=False)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "<bound method HttpClient.close_connections of <clickhouse_connect.driver.httpclient.HttpClient object at 0x105fd64d0>>"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ch_TEST_BETA_client.close_connections"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "<clickhouse_connect.driver.summary.QuerySummary at 0x11f900810>"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ch_TEST_BETA_client.command(\"\"\"\n",
    "RENAME DATABASE redb TO orig_redb;\n",
    "\"\"\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## DB Creation (schema 2025-08-02)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "ch_TEST_client.command(\"\"\"\n",
    "CREATE DATABASE IF NOT EXISTS redb;\n",
    "\"\"\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Define General Tables"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "### CREATE FULL REDB DATABASE\n",
    "def create_redb_with_all_tables(client):\n",
    "    client.command(\"\"\"\n",
    "        CREATE DATABASE IF NOT EXISTS redb\n",
    "    \"\"\")\n",
    "    create_all_general_tables(client)\n",
    "    create_all_pe_tables(client)\n",
    "\n",
    "#### CREATE FULL TABLES\n",
    "def create_all_general_tables(client):\n",
    "    create_basic_properties_dbtable(client)\n",
    "    create_hashes_dbtable(client)\n",
    "    create_capa_dbtable(client)\n",
    "    create_die_dbtable(client)\n",
    "    create_extra_findings_dbtable(client)\n",
    "\n",
    "\n",
    "##################################\n",
    "#### CREATE INDIVIDUAL TABLES ####\n",
    "##################################\n",
    "\n",
    "#### GENERAL TABLES ####\n",
    "# All tables have SETTINGS index_granularity = 8192\n",
    "def create_basic_properties_dbtable(client):\n",
    "    # Create samples_metadata table\n",
    "    client.command(\"\"\"\n",
    "        CREATE TABLE IF NOT EXISTS redb_basic_properties (\n",
    "            sha256 FixedString(64), -- primary key\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            filename Nullable(String),\n",
    "            sample_name String,\n",
    "            filesize UInt64,\n",
    "            file_entropy Float64,\n",
    "            filetype LowCardinality(String),\n",
    "            filetype_mime LowCardinality(String),\n",
    "            filetype_magika LowCardinality(String),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        PRIMARY KEY (sha256)\n",
    "        ORDER BY (sha256)\n",
    "    \"\"\")\n",
    "\n",
    "def create_hashes_dbtable(client):\n",
    "    # Create hashes table\n",
    "    client.command(\"\"\"\n",
    "        CREATE TABLE IF NOT EXISTS redb_hashes (\n",
    "            sha256 FixedString(64), -- primary key\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            ssdeep_hash Nullable(String),\n",
    "            tlsh_hash Nullable(String),\n",
    "            authentihash Nullable(String),\n",
    "            imphash Nullable(String),\n",
    "            impfuzzy Nullable(String),\n",
    "            typerefhash Nullable(String),\n",
    "            richhash Nullable(String),\n",
    "            richpe_hash Nullable(String),\n",
    "            richpv_hash Nullable(String),\n",
    "            richpv_hash_sorted Nullable(String),\n",
    "            dhash Nullable(String),\n",
    "            analysis_date DateTime64(3, 'UTC')\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        PRIMARY KEY (sha256)\n",
    "        ORDER BY (sha256)\n",
    "    \"\"\")\n",
    "\n",
    "def create_capa_dbtable(client):\n",
    "    # Create sample_capabilities table\n",
    "    client.command(\"\"\"\n",
    "        SET enable_json_type = 1;\n",
    "    \"\"\")\n",
    "    client.command(\"\"\"\n",
    "        -- Base table for CAPA analysis results\n",
    "        CREATE TABLE IF NOT EXISTS redb_capa (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "            -- Store full JSON dumps as strings for flexibility\n",
    "            capa_dump JSON CODEC(ZSTD(3)),\n",
    "            attack_dump JSON CODEC(ZSTD(3)),\n",
    "            mbc_dump JSON CODEC(ZSTD(3))\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        ORDER BY sha256;\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Normalized table for capabilities and namespaces\n",
    "        CREATE TABLE IF NOT EXISTS redb_capa_capabilities (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "            namespace LowCardinality(String),\n",
    "            capability LowCardinality(String)\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        ORDER BY (sha256, namespace, capability);\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Materialized view for capability statistics\n",
    "        CREATE MATERIALIZED VIEW IF NOT EXISTS redb_capa_capabilities_stats (\n",
    "            namespace LowCardinality(String),\n",
    "            capability LowCardinality(String),\n",
    "            samples_bitmap AggregateFunction(groupBitmap, UInt64),\n",
    "            occurrence_count UInt64\n",
    "        ) ENGINE = AggregatingMergeTree()\n",
    "        ORDER BY (namespace, capability)\n",
    "        AS SELECT\n",
    "            namespace,\n",
    "            capability,\n",
    "            groupBitmapState(cityHash64(sha256)) as samples_bitmap,\n",
    "            count() as occurrence_count\n",
    "        FROM redb_capa_capabilities\n",
    "        GROUP BY namespace, capability;\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Normalized table for MITRE ATT&CK mappings\n",
    "        CREATE TABLE IF NOT EXISTS redb_capa_attack (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "            tactic LowCardinality(String),\n",
    "            technique LowCardinality(String),\n",
    "            technique_id LowCardinality(String)\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        ORDER BY (sha256, tactic, technique_id);\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Materialized view for ATT&CK statistics\n",
    "        CREATE MATERIALIZED VIEW IF NOT EXISTS redb_capa_attack_stats (\n",
    "            tactic LowCardinality(String),\n",
    "            technique LowCardinality(String),\n",
    "            technique_id LowCardinality(String),\n",
    "            samples_bitmap AggregateFunction(groupBitmap, UInt64),\n",
    "            occurrence_count UInt64\n",
    "        ) ENGINE = AggregatingMergeTree()\n",
    "        ORDER BY (tactic, technique_id)\n",
    "        AS SELECT\n",
    "            tactic,\n",
    "            technique,\n",
    "            technique_id,\n",
    "            groupBitmapState(cityHash64(sha256)) as samples_bitmap,\n",
    "            count() as occurrence_count\n",
    "        FROM redb_capa_attack\n",
    "        GROUP BY tactic, technique, technique_id;\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Normalized table for MBC mappings\n",
    "        CREATE TABLE IF NOT EXISTS redb_capa_mbc (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "            objective LowCardinality(String),\n",
    "            behavior LowCardinality(String),\n",
    "            behavior_id LowCardinality(String)\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        ORDER BY (sha256, objective, behavior_id);\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        -- Materialized view for MBC statistics\n",
    "        CREATE MATERIALIZED VIEW IF NOT EXISTS redb_capa_mbc_stats (\n",
    "            objective LowCardinality(String),\n",
    "            behavior LowCardinality(String),\n",
    "            behavior_id LowCardinality(String),\n",
    "            samples_bitmap AggregateFunction(groupBitmap, UInt64),\n",
    "            occurrence_count UInt64\n",
    "        ) ENGINE = AggregatingMergeTree()\n",
    "        ORDER BY (objective, behavior_id)\n",
    "        AS SELECT\n",
    "            objective,\n",
    "            behavior,\n",
    "            behavior_id,\n",
    "            groupBitmapState(cityHash64(sha256)) as samples_bitmap,\n",
    "            count() as occurrence_count\n",
    "        FROM redb_capa_mbc\n",
    "        GROUP BY objective, behavior, behavior_id;\n",
    "    \"\"\")\n",
    "\n",
    "def create_die_dbtable(client):\n",
    "    # Create sample_die table\n",
    "    client.command(\"\"\"\n",
    "        SET enable_json_type = 1;\n",
    "    \"\"\")\n",
    "    client.command(\"\"\"\n",
    "        CREATE TABLE IF NOT EXISTS redb_die (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            die_info JSON CODEC(ZSTD(3)),\n",
    "            analysis_date DateTime64(3, 'UTC')\n",
    "        ) ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        PRIMARY KEY (sha256)\n",
    "        ORDER BY (sha256)\n",
    "    \"\"\")\n",
    "\n",
    "    client.command(\"\"\"\n",
    "        CREATE MATERIALIZED VIEW redb_die_mv\n",
    "        (\n",
    "            sha256 FixedString(64),\n",
    "            md5 FixedString(32),\n",
    "            sha1 FixedString(40),\n",
    "            analysis_date DateTime64(3, 'UTC'),\n",
    "            compiler LowCardinality(Nullable(String)),\n",
    "            compiler_full Nullable(String),\n",
    "            format LowCardinality(Nullable(String)),\n",
    "            format_full Nullable(String),\n",
    "            installer LowCardinality(Nullable(String)),\n",
    "            installer_full Nullable(String),\n",
    "            joiner LowCardinality(Nullable(String)),\n",
    "            joiner_full Nullable(String),\n",
    "            language LowCardinality(Nullable(String)),\n",
    "            language_full Nullable(String),\n",
    "            library LowCardinality(Nullable(String)),\n",
    "            library_full Nullable(String),\n",
    "            linker LowCardinality(Nullable(String)),\n",
    "            linker_full Nullable(String),\n",
    "            operation_system LowCardinality(Nullable(String)),\n",
    "            operation_system_full Nullable(String),\n",
    "            packer LowCardinality(Nullable(String)),\n",
    "            packer_full Nullable(String),\n",
    "            protector LowCardinality(Nullable(String)),\n",
    "            protector_full Nullable(String),\n",
    "            sfx LowCardinality(Nullable(String)),\n",
    "            sfx_full Nullable(String),\n",
    "            sign_tool LowCardinality(Nullable(String)),\n",
    "            sign_tool_full Nullable(String),\n",
    "            stub LowCardinality(Nullable(String)),\n",
    "            stub_full Nullable(String),\n",
    "            tool LowCardinality(Nullable(String)),\n",
    "            tool_full Nullable(String),   \n",
    "            -- overlay JSON CODEC(ZSTD(3)),\n",
    "            -- resource JSON CODEC(ZSTD(3)),\n",
    "            has_overlay UInt8,\n",
    "            has_resources UInt8,\n",
    "            is_packed UInt8\n",
    "        )\n",
    "        ENGINE = ReplacingMergeTree(analysis_date)\n",
    "        ORDER BY (sha256)\n",
    "        POPULATE\n",
    "        AS SELECT\n",
    "            sha256,\n",
    "            md5,\n",
    "            sha1,\n",
    "            analysis_date,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'compiler'), '') AS compiler,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'compiler(full)'), '') AS compiler_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'format'), '') AS format,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'format(full)'), '') AS format_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'installer'), '') AS installer,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'installer(full)'), '') AS installer_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'joiner'), '') AS joiner,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'joiner(full)'), '') AS joiner_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'language'), '') AS language,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'language(full)'), '') AS language_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'library'), '') AS library,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'library(full)'), '') AS library_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'linker'), '') AS linker,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'linker(full)'), '') AS linker_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'operation_system'), '') AS operation_system,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'operation_system(full)'), '') AS operation_system_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'packer'), '') AS packer,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'packer(full)'), '') AS packer_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'protector'), '') AS protector,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'protector(full)'), '') AS protector_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'sfx'), '') AS sfx,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'sfx(full)'), '') AS sfx_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'sign_tool'), '') AS sign_tool,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'sign_tool(full)'), '') AS sign_tool_full,\n",
    "            nullIf(JSONExtractString(toString(die_info), 'stub'), '') AS stub,\n",
    "            nullIf(JSONExtractString(toString(die_info),