Holger Fröhlich

77 papers A* 2A 2B 10C 1Journal 56Unranked 5

Year	Rank	Type	Title / Venue / Authors
2025	J	`jnl`	Author Correction: Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson's disease. npj Digit. Medicine Cyril Brzenczek, Quentin Klopfenstein, Tom Hähnel, Stefano Sapienza, Jochen Klucken, Holger Fröhlich, Enrico Glaab, NCER-PD Consortium
2025	J	`jnl`	Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies. npj Digit. Medicine Ulrike Weirauch, Markus Kreuz, Colin Birkenbihl, Miriam Alb, Maria Quaranta, Laurence Calzone, Sophia Orozco-Ruiz, Stefanie Binder, Luise Fischer, Solène Clavreul, Morine Maguri, Maximilian Ferle, Michael Rade, Guillaume Azarias, Jay R. Hydren, Jakub Jamarik, Daniel Schwarz, Zsolt Sebestyen, Jurgen Kuball, Georg Popp, Chloé Antoine, Manon Knockaert, Clara T. Schoeder, David Fandrei, Carmen Sanges, Vaclovas Radvilas, Nico Gagelmann, Markus Rückert, Olaf Penack, Stephan Fricke, Andreas Schmidt, Carol Ward, Carl Steinbeisser, Anna Niarakis, Laurent Garderet, Michael Hudecek, Thomas Neumuth, Uwe Platzbecker, Ulrike Köhl, Regina Demlova, Andreas Kremer, Stefan Franke, Holger Fröhlich, Maximilian Merz, Kristin Reiche, Jean-Marc Van Gyseghem
2025	J	`jnl`	Improving Representation Learning of Complex Critical Care Data with ICU-BERT. CoRR Ricardo Santos, André V. Carreiro, Xi Peng, Hugo Gamboa, Holger Fröhlich
2024	J	`jnl`	Dataset of miRNA-disease relations extracted from textual data using transformer-based neural networks. Database J. Biol. Databases Curation Sumit Madan, Lisa Kühnel, Holger Fröhlich, Martin Hofmann-Apitius, Juliane Fluck
2024	—	`conf`	INDEX: the Intelligent Data Steward Toolbox. Utilizing Large Language Model embeddings for automated data harmonization. SWAT4HCLS Tim Adams, Mohamed Aborageh, Yasamin Salimi, Holger Fröhlich, Marc Jacobs
2024	J	`jnl`	Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson's disease. npj Digit. Medicine Cyril Brzenczek, Quentin Klopfenstein, Tom Hähnel, Holger Fröhlich, Enrico Glaab, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Muhammad Ali, Wim Ammerlann, Giuseppe Arena, Michele Bassis, Roxane Batutu, Katy Beaumont, Sibylle Béchet, Guy Berchem, Alexandre Bisdorff, Ibrahim Boussaad, David Bouvier, Lorieza Castillo, Gessica Contesotto, Nancy De Bremaeker, Brian Dewitt, Nico Diederich, Rene Dondelinger, Nancy E. Ramia, Angelo Ferrari, Katrin Frauenknecht, Joëlle Fritz, Carlos Gamio, Manon Gantenbein, Piotr Gawron, Laura Georges, Soumyabrata Ghosh, Marijus Giraitis, Martine Goergen, Elisa Gómez de Lope, Jérôme Graas, Mariella Graziano, Valentin Grouès, Anne Grünewald, Gaël Hammot, Anne-Marie Hanff, Linda Hansen, Michael Heneka, Estelle Henry, Margaux Henry, Sylvia Herbrink, Sascha Herzinger, Alexander Hundt, Nadine Jacoby, Sonja Jónsdóttir, Jochen Klucken, Olga Kofanova, Rejko Krüger, Pauline Lambert, Zied Landoulsi, Roseline Lentz, Ana Festas Lopes, Victoria Lorentz, Tainá M. Marques, Guilherme Marques, Patricia Martins Conde, Patrick May, Deborah Mcintyre, Chouaib Mediouni, Francoise Meisch, Alexia Mendibide, Myriam Menster, Maura Minelli, Michel Mittelbronn, Saïda Mtimet, Maeva Munsch, Romain Nati, Ulf Nehrbass, Sarah Nickels, Beatrice Nicolai, Jean-Paul Nicolay, Maria Fernanda Niño Uribe, Fozia Noor, Clarissa P. C. Gomes, Sinthuja Pachchek, Claire Pauly, Laure Pauly, Lukas Pavelka, Magali Perquin, Achilleas Pexaras, Armin Rauschenberger, Rajesh Rawal, Dheeraj Reddy Bobbili, Lucie Remark, Ilsé Richard, Olivia Roland, Kirsten Roomp, Eduardo Rosales, Stefano Sapienza, Venkata P. Satagopam, Sabine Schmitz, Reinhard Schneider, Jens Schwamborn, Raquel Severino, Amir Sharify, Ruxandra Soare, Ekaterina Soboleva, Kate Sokolowska, Maud Theresine, Hermann Thien, Elodie Thiry, Rebecca Ting Jiin Loo, Johanna Trouet, Olena Tsurkalenko, Michel Vaillant, Carlos Vega, Liliana Vilas Boas, Paul Wilmes, Evi Wollscheid-Lengeling, Gelani Zelimkhanov
2024	—	`conf`	NFDI4Health Workflow and Service for Synthetic Data Generation, Assessment and Risk Management. GMDS Sobhan Moazemi, Tim Adams, Hwei Geok Ng, Lisa Kühnel, Julian Schneider, Anatol-Fiete Näher, Juliane Fluck, Holger Fröhlich
2024	J	`jnl`	NFDI4Health workflow and service for synthetic data generation, assessment and risk management. CoRR Sobhan Moazemi, Tim Adams, Hwei Geok Ng, Lisa Kühnel, Julian Schneider, Anatol-Fiete Näher, Juliane Fluck, Holger Fröhlich
2024	—	`conf`	Privacy Risk Assessment for Synthetic Longitudinal Health Data. GMDS Julian Schneider, Marvin Walter, Karen Otte, Thierry Meurers, Ines Perrar, Ute Nöthlings, Tim Adams, Holger Fröhlich, Fabian Prasser, Juliane Fluck, Lisa Kühnel
2024	J	`jnl`	Regulatory considerations for developing remote measurement technologies for Alzheimer's disease research. npj Digit. Medicine Gül Erdemli, Margarita Grammatikopoulou, Bertil Wagner, Srinivasan Vairavan, Jelena Curcic, Dag Aarsland, Gayle Wittenberg, Spiros Nikolopoulos, Marijn Muurling, Holger Fröhlich, Casper de Boer, Niraj M. Shanbhag, Vera J. M. Nies, Neva Coello, Dianne Gove, Ana Diaz, Suzanne Foy, Wim Dartee, Anna-Katharine Brem
2024	J	`jnl`	Transformer models in biomedicine. BMC Medical Informatics Decis. Mak. Sumit Madan, Manuel Lentzen, Johannes Brandt, Daniel Rueckert, Martin Hofmann-Apitius, Holger Fröhlich
2023	J	`jnl`	A Transformer-Based Model Trained on Large Scale Claims Data for Prediction of Severe COVID-19 Disease Progression. IEEE J. Biomed. Health Informatics Manuel Lentzen, Thomas Linden, Sai Veeranki, Sumit Madan, Diether Kramer, Werner Leodolter, Holger Fröhlich
2023	J	`jnl`	AI reveals insights into link between CD33 and cognitive impairment in Alzheimer's Disease. PLoS Comput. Biol. Tamara Raschka, Meemansa Sood, Bruce Schultz, Aybuge Altay, Christian Ebeling, Holger Fröhlich
2023	J	`jnl`	Synthetic data generation for a longitudinal cohort study - Evaluation, method extension and reproduction of published data analysis results. CoRR Lisa Kühnel, Julian Schneider, Ines Perrar, Tim Adams, Fabian Prasser, Ute Nöthlings, Holger Fröhlich, Juliane Fluck
2023	J	`jnl`	Towards early diagnosis of Alzheimer's disease: Advances in immune-related blood biomarkers and computational modeling approaches. CoRR Sophia Krix, Ella Wilczynski, Neus Falgàs, Raquel Sánchez-Valle, Eti Yoles, Uri Nevo, Kuti Baruch, Holger Fröhlich
2022	J	`jnl`	Accurate prediction of virus-host protein-protein interactions via a Siamese neural network using deep protein sequence embeddings. Patterns Sumit Madan, Victoria Demina, Marcus Stapf, Oliver Ernst, Holger Fröhlich
2022	J	`jnl`	Deep Learning-based detection of psychiatric attributes from German mental health records. Int. J. Medical Informatics Sumit Madan, Fabian Julius Zimmer, Helena Balabin, Sebastian Schaaf, Holger Fröhlich, Juliane Fluck, Irene Neuner, Klaus Mathiak, Martin Hofmann-Apitius, Pegah Sarkheil
2022	J	`jnl`	GenRisk: a tool for comprehensive genetic risk modeling. Bioinform. Rana Aldisi, Emadeldin Hassanin, Sugirthan Sivalingam, Andreas Buness, Hannah Klinkhammer, Andreas Mayr, Holger Fröhlich, Peter M. Krawitz, Carlo Maj
2022	J	`jnl`	Generation of realistic synthetic data using Multimodal Neural Ordinary Differential Equations. npj Digit. Medicine Philipp Wendland, Colin Birkenbihl, Marc Gomez-Freixa, Meemansa Sood, Maik Kschischo, Holger Fröhlich
2022	J	`jnl`	GuiltyTargets: Prioritization of Novel Therapeutic Targets With Network Representation Learning. IEEE ACM Trans. Comput. Biol. Bioinform. Ozlem Muslu, Charles Tapley Hoyt, Mauricio Lacerda, Martin Hofmann-Apitius, Holger Fröhlich
2022	J	`jnl`	Ten quick tips for biomarker discovery and validation analyses using machine learning. PLoS Comput. Biol. Ramón Díaz-Uriarte, Elisa Gómez de Lope, Rosalba Giugno, Holger Fröhlich, Petr V. Nazarov, Isabel A. Nepomuceno-Chamorro, Armin Rauschenberger, Enrico Glaab
2021	J	`jnl`	An Explainable Multimodal Neural Network Architecture for Predicting Epilepsy Comorbidities Based on Administrative Claims Data. Frontiers Artif. Intell. Thomas Linden, Johann de Jong, Chao Lu, Victor Kiri, Kathrin Haeffs, Holger Fröhlich
2021	J	`jnl`	SEEDS: data driven inference of structural model errors and unknown inputs for dynamic systems biology. Bioinform. Tobias Newmiwaka, Benjamin Engelhardt, Philipp Wendland, Dominik Kahl, Holger Fröhlich, Maik Kschischo
2020	J	`jnl`	PathME: pathway based multi-modal sparse autoencoders for clustering of patient-level multi-omics data. BMC Bioinform. Amina Lemsara, Salima Ouadfel, Holger Fröhlich
2020	J	`jnl`	Variational Autoencoder Modular Bayesian Networks for Simulation of Heterogeneous Clinical Study Data. Frontiers Big Data Luise Gootjes-Dreesbach, Meemansa Sood, Akrishta Sahay, Martin Hofmann-Apitius, Holger Fröhlich
2019	J	`jnl`	MCMC Techniques for Parameter Estimation of ODE Based Models in Systems Biology. Frontiers Appl. Math. Stat. Gloria I. Valderrama-Bahamóndez, Holger Fröhlich
2018	J	`jnl`	A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System. IEEE Trans. Biomed. Eng. Holger Fröhlich, Kasper Claes, Catherine De Wolf, Xavier Van Damme, Anne Michel
2017	J	`jnl`	Addressing the Computational Challenges of Personalized Medicine (Dagstuhl Seminar 17472). Dagstuhl Reports Niko Beerenwinkel, Holger Fröhlich, Susan A. Murphy
2017	J	`jnl`	Inferring modulators of genetic interactions with epistatic nested effects models. PLoS Comput. Biol. Martin Pirkl, Madeline Diekmann, Marlies van der Wees, Niko Beerenwinkel, Holger Fröhlich, Florian Markowetz
2017	J	`jnl`	Linking metabolic network features to phenotypes using sparse group lasso. Bioinform. Satya Swarup Samal, Ovidiu Radulescu, Andreas Weber, Holger Fröhlich
2017	J	`jnl`	Towards clinically more relevant dissection of patient heterogeneity via survival-based Bayesian clustering. Bioinform. Ashar Ahmad, Holger Fröhlich
2015	B	`conf`	Analysis of Reaction Network Systems Using Tropical Geometry. CASC Satya Swarup Samal, Dima Grigoriev, Holger Fröhlich, Ovidiu Radulescu
2015	J	`jnl`	NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation. PLoS Comput. Biol. Juliane Siebourg-Polster, Daria Mudrak, Mario Emmenlauer, Pauli Rämö, Christoph Dehio, Urs F. Greber, Holger Fröhlich, Niko Beerenwinkel
2015	J	`jnl`	biRte: Bayesian inference of context-specific regulator activities and transcriptional networks. Bioinform. Holger Fröhlich
2014	J	`jnl`	TGF-beta stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Syst. Biol. Khalid Abnaof, Nikhil Mallela, Gudrun Walenda, Steffen Meurer, Kristin Seré, Qiong Lin, Bert Smeets, Kurt Hoffmann, Wolfgang Wagner, Martin Zenke, Ralf Weiskirchen, Holger Fröhlich
2014	J	`jnl`	netClass: an R-package for network based, integrative biomarker signature discovery. Bioinform. Yupeng Cun, Holger Fröhlich
2013	J	`jnl`	Learning gene network structure from time laps cell imaging in RNAi Knock downs. Bioinform. Henrik Failmezger, Paurush Praveen, Achim Tresch, Holger Fröhlich
2013	J	`jnl`	Predicting Potent Compounds via Model-Based Global Optimization. J. Chem. Inf. Model. Mohsen Ahmadi, Martin Vogt, Preeti Iyer, Jürgen Bajorath, Holger Fröhlich
2013	—	`conf`	Reconstructing Consensus Bayesian Network Structures with Application to Learning Molecular Interaction Networks. GCB Holger Fröhlich, Gunnar W. Klau
2013	J	`jnl`	Steiner tree methods for optimal sub-network identification: an empirical study. BMC Bioinform. Afshin Sadeghi, Holger Fröhlich
2013	J	`jnl`	Unsupervised automated high throughput phenotyping of RNAi time-lapse movies. BMC Bioinform. Henrik Failmezger, Holger Fröhlich, Achim Tresch
2012	J	`jnl`	Immune System Modeling and Related Pathologies. Comput. Math. Methods Medicine Francesco Pappalardo, Vladimir Brusic, Holger Fröhlich
2012	J	`jnl`	Joint Bayesian inference of condition-specific miRNA and transcription factor activities from combined gene and microRNA expression data. Bioinform. Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Fröhlich
2012	J	`jnl`	MC EMiNEM Maps the Interaction Landscape of the Mediator. PLoS Comput. Biol. Theresa Niederberger, Stefanie Etzold, Michael Lidschreiber, Kerstin C. Maier, Dietmar E. Martin, Holger Fröhlich, Patrick Cramer, Achim Tresch
2012	J	`jnl`	Prognostic gene signatures for patient stratification in breast cancer - accuracy, stability and interpretability of gene selection approaches using prior knowledge on protein-protein interactions. BMC Bioinform. Yupeng Cun, Holger Fröhlich
2011	J	`jnl`	Fast and efficient dynamic nested effects models. Bioinform. Holger Fröhlich, Paurush Praveen, Achim Tresch
2011	J	`jnl`	pathClass: an R-package for integration of pathway knowledge into support vector machines for biomarker discovery. Bioinform. Marc Johannes, Holger Fröhlich, Holger Sültmann, Tim Beißbarth
2010	J	`jnl`	Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array data. Bioinform. Christian Bender, Frauke Henjes, Holger Fröhlich, Stefan Wiemann, Ulrike Korf, Tim Beißbarth
2010	J	`jnl`	Integration of pathway knowledge into a reweighted recursive feature elimination approach for risk stratification of cancer patients. Bioinform. Marc Johannes, Jan C. Brase, Holger Fröhlich, Stephan Gade, Mathias C. Gehrmann, Maria Fälth, Holger Sültmann, Tim Beißbarth
2009	J	`jnl`	A Bayesian Network View on Nested Effects Models. EURASIP J. Bioinform. Syst. Biol. Cordula Zeller, Holger Fröhlich, Achim Tresch
2009	J	`jnl`	Deterministic Effects Propagation Networks for reconstructing protein signaling networks from multiple interventions. BMC Bioinform. Holger Fröhlich, Özgür Sahin, Dorit Arlt, Christian Bender, Tim Beißbarth
2009	J	`jnl`	Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst. Biol. Özgür Sahin, Holger Fröhlich, Christian Löbke, Ulrike Korf, Sara Burmester, Meher Majety, Jens Mattern, Ingo Schupp, Claudine Chaouiya, Denis Thieffry, Annemarie Poustka, Stefan Wiemann, Tim Beißbarth, Dorit Arlt
2008	J	`jnl`	Analyzing gene perturbation screens with nested effects models in R and bioconductor. Bioinform. Holger Fröhlich, Tim Beißbarth, Achim Tresch, Dennis Kostka, Juby Jacob, Rainer Spang, Florian Markowetz
2008	J	`jnl`	Automated classification of the behavior of rats in the forced swimming test with support vector machines. Neural Networks Holger Fröhlich, Andreas Hoenselaar, Jonas Eichner, Holger Rosenbrock, Gerald Birk, Andreas Zell
2008	J	`jnl`	Estimating large-scale signaling networks through nested effect models with intervention effects from microarray data. Bioinform. Holger Fröhlich, Mark Fellmann, Holger Sültmann, Annemarie Poustka, Tim Beißbarth
2008	J	`jnl`	Predicting pathway membership via domain signatures. Bioinform. Holger Fröhlich, Mark Fellmann, Holger Sültmann, Annemarie Poustka, Tim Beißbarth
2007	—	`conf`	Estimating Large Scale Scale Signaling Networks through Nested Effects Models from Intervention Effects in Microarray Data. German Conference on Bioinformatics Holger Fröhlich, Mark Fellmann, Holger Sültmann, Annemarie Poustka, Tim Beißbarth
2007	J	`jnl`	GOSim - an R-package for computation of information theoretic GO similarities between terms and gene products. BMC Bioinform. Holger Fröhlich, Nora Speer, Annemarie Poustka, Tim Beißbarth
2007	B	`conf`	Gene Regulatory Network Inference via Regression Based Topological Refinement. APBC Jochen Supper, Holger Fröhlich, Andreas Zell
2007	B	`conf`	Inferring Gene Regulatory Networks by Machine Learning Methods. APBC Jochen Supper, Holger Fröhlich, Christian Spieth, Andreas Dräger, Andreas Zell
2007	J	`jnl`	Large scale statistical inference of signaling pathways from RNAi and microarray data. BMC Bioinform. Holger Fröhlich, Mark Fellmann, Holger Sültmann, Annemarie Poustka, Tim Beißbarth
2006	B	`conf`	Kernel Based Functional Gene Grouping. IJCNN Holger Fröhlich, Nora Speer, Christian Spieth, Andreas Zell
2006	—	`—`	Kernel methods in chemo- and bioinformatics. Holger Fröhlich
2006	A	`conf`	Vibration-based Terrain Classification Using Support Vector Machines. IROS Christian Weiss, Holger Fröhlich, Andreas Zell
2005	B	`conf`	Assignment kernels for chemical compounds. IJCNN Holger Fröhlich, Jörg K. Wegner, Andreas Zell
2005	B	`conf`	Efficient parameter selection for support vector machines in classification and regression via model-based global optimization. IJCNN Holger Fröhlich, Andreas Zell
2005	C	`conf`	Functional Distances for Genes Based on GO Feature Maps and their Application to Clustering. CIBCB Nora Speer, Holger Fröhlich, Christian Spieth, Andreas Zell
2005	B	`conf`	Functional grouping of genes using spectral clustering and Gene Ontology. IJCNN Nora Speer, Holger Fröhlich, Christian Spieth, Andreas Zell
2005	A*	`conf`	Optimal assignment kernels for attributed molecular graphs. ICML Holger Fröhlich, Jörg K. Wegner, Florian Sieker, Andreas Zell
2005	B	`conf`	Which features trigger action potentials in cortical neurons in vivo? IJCNN Holger Fröhlich, Björn Naundorf, Maxim Volgushev, Fred Wolf
2004	J	`jnl`	Feature Selection for Descriptor Based Classification Models. 1. Theory and GA-SEC Algorithm. J. Chem. Inf. Model. Jörg K. Wegner, Holger Fröhlich, Andreas Zell
2004	J	`jnl`	Feature Selection for Descriptor Based Classification Models. 2. Human Intestinal Absorption (HIA). J. Chem. Inf. Model. Jörg K. Wegner, Holger Fröhlich, Andreas Zell
2004	J	`jnl`	Feature Selection for Support Vector Machines Using Genetic Algorithms. Int. J. Artif. Intell. Tools Holger Fröhlich, Olivier Chapelle, Bernhard Schölkopf
2004	B	`conf`	Feature subset selection for support vector machines by incremental regularized risk minimization. IJCNN Holger Fröhlich, Andreas Zell
2004	A*	`conf`	Gas Source Declaration with a Mobile Robot. ICRA Achim J. Lilienthal, Andreas Zell, Holger Ulmer, Holger Fröhlich, Andreas Stützle, Felix Werner
2004	A	`conf`	Learning to detect proximity to a gas source with a mobile robot. IROS Achim J. Lilienthal, Holger Ulmer, Holger Fröhlich, Felix Werner, Andreas Zell
2003	B	`conf`	Feature Selection for Support Vector Machines by Means of Genetic Algorithms. ICTAI Holger Fröhlich, Olivier Chapelle, Bernhard Schölkopf