Hirokazu Sugiyama

22 papers Journal 20Unranked 2
YearRankTypeTitle / Venue / Authors
2025 J jnl
Anomaly detection for drug product manufacturing considering data limitations and shifts: A case study on industrial freeze-dryers.
Comput. Chem. Eng.
Gianluca Lombardini, Sara Badr, Christian Schmid, Stephanie Knüppel, Hirokazu Sugiyama
2025 J jnl
Model-based design of mesenchymal stem cell seeding-cultivation-passage processes considering dynamics and variabilities.
Comput. Chem. Eng.
Keita Hirono, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
2024 J jnl
Data-driven parameterization and development of mechanistic cell cultivation models in monoclonal antibody production processes: Shifts in cell metabolic behavior.
Comput. Chem. Eng.
Kozue Okamura, Kota Oishi, Sara Badr, Akira Yamada, Hirokazu Sugiyama
2023 J jnl
A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation.
Comput. Chem. Eng.
Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama
2023 J jnl
Agile process systems engineering education: What to teach, and how to teach.
Comput. Chem. Eng.
Daniel R. Lewin, Emilia M. Kondili, Ian T. Cameron, Grégoire Léonard, Seyed Soheil Mansouri, Fernando Gomes Martins, Luis A. Ricardez-Sandoval, Hirokazu Sugiyama, Edwin Zondervan
2023 J jnl
Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes.
Comput. Chem. Eng.
Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama
2023 J jnl
The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production.
Comput. Chem. Eng.
Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
2022 J jnl
A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells.
Comput. Chem. Eng.
Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama
2022 J jnl
Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality.
Comput. Chem. Eng.
Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
2022 J jnl
Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation.
Comput. Chem. Eng.
Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama
2021 J jnl
Integrated design of biopharmaceutical manufacturing processes: Operation modes and process configurations for monoclonal antibody production.
Comput. Chem. Eng.
Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama
2021 J jnl
Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells.
Comput. Chem. Eng.
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
2020 J jnl
Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation.
Comput. Chem. Eng.
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
2019 J jnl
Alternative generation and multiobjective evaluation using a design framework: Case study on sterile filling processes of biopharmaceuticals.
Comput. Chem. Eng.
Haruku Shirahata, Sara Badr, Shant Dakessian, Hirokazu Sugiyama
2019 J jnl
Data mining algorithm for pre-processing biopharmaceutical drug product manufacturing records.
Comput. Chem. Eng.
Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
2019 — conf
Lasing Characteristics of GalnAsP SCH MQW High-mesa Laser on Silicon Substrate.
OECC/PSC
Koki Tsushima, Kazuki Uchida, Xu Han, Hirokazu Sugiyama, Masaki Aikawa, Natsuki Hayasaka, Masaki Matsuura, Takahiro Ishizaki, Takuto Shirai, Kazuhiko Shimomura
2019 — conf
Lasing characteristics of GalnAsP SCH-MQW Laser Diode on Directly-bonded InP/Si Substrate.
OECC/PSC
Takahiro Ishizaki, Kazuki Uchida, Hirokazu Sugiyama, Xu Han, Natsuki Hayasaka, Masaki Aikawa, Masaki Matsuura, Koki Tsushima, Takuto Shirai, Kazuhiko Shimomura
2019 J jnl
Multiobjective decision-support tools for the choice between single-use and multi-use technologies in sterile filling of biopharmaceuticals.
Comput. Chem. Eng.
Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama
2016 J jnl
Data-driven tiered procedure for enhancing yield in drug product manufacturing.
Comput. Chem. Eng.
Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
2016 J jnl
Rigorous approach to scheduling of sterile drug product manufacturing.
Comput. Chem. Eng.
Lukas Gallus Eberle, Elisabet Capón-García, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
2015 J jnl
Systematic retrofitting methodology for pharmaceutical drug purification processes.
Comput. Chem. Eng.
Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama
2014 J jnl
Improving lead time of pharmaceutical production processes using Monte Carlo simulation.
Comput. Chem. Eng.
Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt